CHEEC initiated a cooperative research program in 1999. It seeks to leverage research monies from university, state, and federal entities to conduct research in areas of mutual interest with collaborators. The collaboration requires matching funds from participating entities. A member of CHEEC's executive committee must serve as a co-investigator. Like the seed grant program, it seeks to establish innovative lines of environmental health research leading to preliminary results that may be used in seeking further larger grant funding from federal and private sources.

The following are CHEEC cooperative research efforts:

Naturally-occurring radioactivity in private drinking water in Iowa: Understanding the potential for increased cancer risk in Iowans (2016)                                                                                                                                                                         Development of novel, composite nanomaterials for water filtration (2014)
Evaluation of a Web-Based Approach to Data Collection in Molecular Environmental Epidemiological Investigations of Adverse Pregnancy Outcomes (2012)
Occurrence of Viruses and Unregulated Contaminants in Iowa Public Water Supply Groundwater (2012)
Influence of Redox Fluctuations on Arsenic Dynamics in Iowa Aquifer Materials (2011)
Iowa Statewide Rural Well Water Survey Phase 2 (2006-2008)
The Iowa Beach Study (2005)
Fate of Endocrine Disruptors, Antibiotics and Pharmaceuticals in Wastewater Treatment Plants (2004)
Urinary Pesticide Metabolite Levels and Reproductive Effects: A Prospective, Pilot Study of Partners of Pregnant Women in Iowa (2003)
Iowa Community Private Well Study (2002)
Analysis of Environmental Exposures in Hoop Structures and Conventional Confinement Swine Barns (1999)
Antibiotics in Surface Water (1999)