Effect of In Utero Exposure to PCB 136 (2,2',3,3',6,6'- Hexachlorobiphenyl) Enantiomers on Neurodevelopmental Outcomes in Adult Offspring
I. Kania-Korwel, and HJ Lehmler, Department of Occupational and Environmental Health, University of Iowa
Polychlorinated biphenyls (PCBs) are a group of industrial chemicals that persist in the environment and cause adverse neurodevelopmental effects (such as altered brain ryanodine binding) in laboratory animals and in humans. Several neurotoxic PCB congeners, such as PCB 136, are chiral and, as we have shown recently, sensitize ryanodine receptors in an enantiospecific manner in vitro. We hypothesize that exposure to PCB 136 during gestation and lactation causes long-term neurodevelopmental effects in an enantiomer specific manner, with (-)-PCB 136 being more potent and efficacious than (+)-PCB 136. This hypothesis will be tested by investigating enantiomer specific differences (1) in the profile of PCB 136 and its metabolites and (2) brain ryanodine binding in mice exposed during gestation and lactation to (+)- and (-)-PCB 136.
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