Feasibility study of DNA flow cytometry in renal cell and colorectal carcinoma among Iowa residents

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Project Period: 
Project Investigator(s): 
CF Lynch, Department of Preventive Medicine and Environmental Health; R Robinson, Department of Pathology, The University of Iowa

This study researched the feasibility of performing DNA ploidy analysis on formalin-fixed tissue from patients who participated in a statewide, population-based, case-control study, and who had tumorous tissue removed at the University of Iowa Hospitals and Clinics. Eligible cancer sites included the kidney, colon, and rectum. A data collection form was developed and ploidy analysis was run. These analysis were correlated with known pathologic predictors of outcome, as well as with known risk factors for colorectal carcinoma. Results showed no strong associations between ploidy status and survival predictors nor with any dietary and other potential risk factors.